Stem cells are a promising therapy for stroke and other brain injuries–they can sprout into healthy neurons and may be able to re-establish brain activity in brain-injured patients. While preliminary animal research shows promise, there’s often a common hurdle: adult stem cells have a hard time growing in damaged areas and tend to migrate to healthier regions of the brain.
That makes sense, says Thomas Webster, associate professor of engineering at Brown University, because healthy neurons emit proteins that attract stem cells away from diseased, inactive areas. What’s needed is an “anchor” to keep stem cells fixed to the damaged areas, where they can then differentiate into working neurons, he says.